Extracts of Neptunia prostrata Linn. ameliorates progression of diabetes mellitus and hyperlipidemia in animal models

Background: The herb Neptunia prostrata Linn. belonging to the family Mimosaceae has been used in folkloric medicine North-eastern states of India Assam, Tripura and Meghalaya by indigenous herbal healers since time immemorial but there is a scarcity any background study documenting its use as an antimicrobial herb. For same, plants were collected authenticated. Methods: Following identification these herbs methanolic, ethanolic, pet ether chloroform extracts prepared using soxhlation. Acute toxicity per OECD guidelines 420 was assessed wistar albino rats swiss mice (n=5) both sexes at doses 2000 mg/kg body weight did not reveal morbidity or mortality animals within stipulated period. Phytochemical screening performed on all four prostrata. Results: constituents depicted presence glycoside, flavonoids only methanolic extracts. Alkaloids present extract. antidiabetic antihyperlipidemic activity HFD-STZ models rats. showed antioxidant comparable standard antioxidants in-vitro such Ascorbic acid (Vitamin C) with IC50 values. Conclusions: Results shows immense potential animal therapeutics antibacterial suggests conspicuous potent putative role vast plethora bacterial infections that need be corroborated for expansion future prospective vivo studies larger sample size.